Preparation of 30 ml Piperazine Citrate Elixir IP with Virtual Interactive Simulation
Table of Contents
Practical Significance
Piperazine citrate elixir is primarily used to treat roundworm and pinworm infections in humans. Its practical significance lies in its effectiveness in eliminating these parasitic infections, which can cause discomfort and health issues if left untreated. Through this experiment students will learn about formulation, method of preparation, labelling aspects, storage, use, direction and evaluation of Piperazine citrate elixir I.P.
Relevant Theoretical Background
Elixirs are clear, sweetened and flavoured hydroalcoholic liquid preparation intended for oral use. The elixir is further classified into flavoured elixir and Medicated elixir. Flavored elixir does not contain any medicament but contains flavoured substances whereas Medicated elixir contains medicinal substances. Piperazine citrate elixir is primarily used as an anthelmintic to treat roundworm and pinworm infections in humans. It paralyzes the worms and makes them pass in the stool. In this preparation chloroform spirit acts as preservative, glycerin as a co-solvent, orange oil as flavouring agent and syrup as sweetening agent.
Requirements
a. Apparatus: 100 ml beaker, Glass rod, 100 ml measuring cylinder, narrow mouth glass bottle.
b. Equipment: Calibrated weighing balance.
c. Chemicals: Piperazine citrate, chloroform spirit, glycerin, orange oil, syrup Purified water.
Formulation Table
Procedure
- a. Weigh the required quantity of piperazine citrate and mix with a part of purified water.
- b. Add the required quantity of chloroform spirit, glycerin, orange oil and syrup and make up the volume by adding purified water.
- c. Evaluate formulation as per evaluation parameters and note the observations.
- d. Transfer into the container, attach a prepared label and submit.
Use of Preparation
Anthelmintic
Direction
As directed by physician
Storage
It should be stored in a well closed container in a cool and dry place and protected from light.
Dose
4-15 ml daily in a divided dose.
Result
________ml of Piperazine citrate elixir IP is prepared, evaluated and submitted in a__________________________ container with special instructions as_______________________
Virtual Interactive Simulation
[embeddoc url=”https://teachntest.wordpress.com/wp-content/uploads/2025/07/2d424-piperazine-citrate-elixir-ip-1.ppsx”]Instructions:
Click “Start,” “Next,” or “End” to navigate between slides.
Follow the sequence order for the best experience.
Allow each animation to complete before moving to the next step.
The actual process may vary slightly from the steps above.
For any suggestions or corrections, please email pankajvalvi@gmail.com.
FAQ’s
a. Define Elixir
Elixirs are clear, sweetened, hydroalcoholic solutions containing active ingredients for oral use.
b. What are the two types of Elixir?
Medicated elixirs: Contain therapeutic agents.
Non-medicated elixirs: Used as vehicles for drug formulation.
c. Explain the formulation of elixir
Elixirs consist of:
Active ingredients: Provide therapeutic effects.
Solvents: A mix of water and alcohol for solubility.
Sweeteners: Enhance taste (e.g., sucrose or saccharin).
Flavoring agents: Improve palatability.
Preservatives: Prevent microbial growth.
d. Name the preservatives added in Piperazine Citrate Elixir I.P.
Chloroform.
e. Name the co-solvent used in Piperazine Citrate Elixir I.P.
Glycerin.
f. Write the mechanism of action of Piperazine Citrate Elixir I.P.
Piperazine citrate paralyzes helminths by blocking neuromuscular transmission, causing worms to lose grip and be expelled from the host’s intestine.